Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson’s disease
Identifieur interne : 000936 ( Main/Exploration ); précédent : 000935; suivant : 000937Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson’s disease
Auteurs : Mike A. Nalls [États-Unis] ; Nathan Pankratz [États-Unis] ; Christina M. Lill [Allemagne] ; Chuong B. Do [États-Unis] ; Dena G. Hernandez [États-Unis] ; Mohamad Saad [États-Unis, France] ; Anita L. Destefano [États-Unis] ; Eleanna Kara [Royaume-Uni] ; Jose Bras [Royaume-Uni] ; Manu Sharma [Allemagne] ; Claudia Schulte [Allemagne] ; Margaux F. Keller [États-Unis] ; Sampath Arepalli [États-Unis] ; Christopher Letson [États-Unis] ; Connor Edsall [États-Unis] ; Hreinn Stefansson [Islande] ; Xinmin Liu [États-Unis] ; Hannah Pliner [États-Unis] ; Joseph H. Lee [États-Unis] ; Rong Cheng [États-Unis] ; M. Arfan Ikram [Pays-Bas] ; John P. A. Ioannidis [États-Unis] ; Georgios M. Hadjigeorgiou [Grèce] ; Joshua C. Bis [États-Unis] ; Maria Martinez [France] ; Joel S. Perlmutter [États-Unis] ; Alison Goate [États-Unis] ; Karen Marder [États-Unis] ; Brian Fiske [États-Unis] ; Margaret Sutherland [États-Unis] ; Georgia Xiromerisiou [Grèce] ; Richard H. Myers [États-Unis] ; Lorraine N. Clark [États-Unis] ; Kari Stefansson [Islande] ; John A. Hardy ; Peter Heutink [Allemagne] ; Honglei Chen [États-Unis] ; Nicholas W. Wood [Royaume-Uni] ; Henry Houlden [Royaume-Uni] ; Haydeh Payami [États-Unis] ; Alexis Brice [France] ; William K. Scott [États-Unis] ; Thomas Gasser [Allemagne] ; Lars Bertram [Allemagne] ; Nicholas Eriksson [États-Unis] ; Tatiana Foroud [États-Unis] ; Andrew B. Singleton [États-Unis]Source :
- Nature genetics [ 1061-4036 ] ; 2014.
English descriptors
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Abstract
We conducted a meta analysis of Parkinson’s disease genome-wide association studies using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty-six loci were identified as genome-wide significant; these and six additional previously reported loci were then tested in an independent set of 5,353 cases and 5,551 controls. Of the 32 tested SNPs, 24 replicated, including 6 novel loci. Conditional analyses within loci show four loci including
Url:
DOI: 10.1038/ng.3043
PubMed: 25064009
PubMed Central: 4146673
Affiliations:
- Allemagne, France, Grèce, Islande, Pays-Bas, Royaume-Uni, États-Unis
- Angleterre, Bade-Wurtemberg, Berlin, Californie, Caroline du Nord, District de Tübingen, Grand Londres, Hollande-Méridionale, Indiana, Maryland, Massachusetts, Midi-Pyrénées, Minnesota, Missouri (État), Occitanie (région administrative), Rhénanie-Palatinat, Washington (État), État de New York, Île-de-France
- Berlin, Londres, Mayence, Paris, Rotterdam, Seattle, Toulouse, Tübingen
- University College de Londres, Université de Washington
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Lee</name><affiliation wicri:level="2"><nlm:aff id="A18">The Taub Institute for Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, new York, NY 10032</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>The Taub Institute for Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, new York</wicri:cityArea></affiliation></author><author><name sortKey="Cheng, Rong" sort="Cheng, Rong" uniqKey="Cheng R" first="Rong" last="Cheng">Rong Cheng</name><affiliation wicri:level="2"><nlm:aff id="A18">The Taub Institute for Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, new York, NY 10032</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>The Taub Institute for Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, new York</wicri:cityArea></affiliation></author><author><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M. Arfan" last="Ikram">M. Arfan Ikram</name><affiliation wicri:level="3"><nlm:aff id="A20">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A21">Department of Radiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Radiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A22">Department of Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name><affiliation wicri:level="1"><nlm:aff id="A23">Stanford Prevention Research Center, Stanford University, Stanford, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanford Prevention Research Center, Stanford University, Stanford</wicri:regionArea><wicri:noRegion>Stanford</wicri:noRegion></affiliation></author><author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name><affiliation wicri:level="1"><nlm:aff id="A24">Neuroscience Unit, Department of Neurology, Faculty of Medicine, University of Thessaly, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Neuroscience Unit, Department of Neurology, Faculty of Medicine, University of Thessaly</wicri:regionArea><wicri:noRegion>University of Thessaly</wicri:noRegion></affiliation></author><author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name><affiliation wicri:level="2"><nlm:aff id="A25">Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Martinez, Maria" sort="Martinez, Maria" uniqKey="Martinez M" first="Maria" last="Martinez">Maria Martinez</name><affiliation wicri:level="3"><nlm:aff id="A8">Institut National de la Sante et de la Recherche Medicale, UMR 1043, Centre de Physiopathologie de Toulouse-Purpan, Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Sante et de la Recherche Medicale, UMR 1043, Centre de Physiopathologie de Toulouse-Purpan, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A9">Paul Sabatier University, Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paul Sabatier University, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S." last="Perlmutter">Joel S. Perlmutter</name><affiliation wicri:level="2"><nlm:aff id="A26">Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO 63110</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A27">Department of Radiology, Washington University School of Medicine, St Louis, MO 63110</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Department of Radiology, Washington University School of Medicine, St Louis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A28">Department of Neurology, Washington University School of Medicine, St Louis, MO 63110</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Department of Neurology, Washington University School of Medicine, St Louis</wicri:cityArea></affiliation></author><author><name sortKey="Goate, Alison" sort="Goate, Alison" uniqKey="Goate A" first="Alison" last="Goate">Alison Goate</name><affiliation wicri:level="2"><nlm:aff id="A26">Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO 63110</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A28">Department of Neurology, Washington University School of Medicine, St Louis, MO 63110</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Department of Neurology, Washington University School of Medicine, St Louis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A29">Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Department of Psychiatry, Washington University School of Medicine, St Louis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A30">Department of Genetics, Washington University School of Medicine, St Louis, MO 63110</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Department of Genetics, Washington University School of Medicine, St Louis</wicri:cityArea></affiliation></author><author><name sortKey="Marder, Karen" sort="Marder, Karen" uniqKey="Marder K" first="Karen" last="Marder">Karen Marder</name><affiliation wicri:level="2"><nlm:aff id="A18">The Taub Institute for Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, new York, NY 10032</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>The Taub Institute for Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, new York</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A31">Gertrude H. Sergievsky Center, Columbia University Medical Center, New York, NY 10032</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Gertrude H. Sergievsky Center, Columbia University Medical Center, New York</wicri:cityArea></affiliation><affiliation><nlm:aff id="A32">Department of Neurology, Columbia University Medical Center. New York</nlm:aff><wicri:noCountry code="subfield">Columbia University Medical Center. New York</wicri:noCountry></affiliation><affiliation><nlm:aff id="A33">Department of Psychiatry, Columbia University Medical Center. New York</nlm:aff><wicri:noCountry code="subfield">Columbia University Medical Center. New York</wicri:noCountry></affiliation></author><author><name sortKey="Fiske, Brian" sort="Fiske, Brian" uniqKey="Fiske B" first="Brian" last="Fiske">Brian Fiske</name><affiliation wicri:level="2"><nlm:aff id="A34">The Michael J. Fox Foundation for Parkinson’s Research, New York, NY</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>The Michael J. Fox Foundation for Parkinson’s Research, New York</wicri:cityArea></affiliation></author><author><name sortKey="Sutherland, Margaret" sort="Sutherland, Margaret" uniqKey="Sutherland M" first="Margaret" last="Sutherland">Margaret Sutherland</name><affiliation wicri:level="2"><nlm:aff id="A35">Neuroscience Center, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Neuroscience Center, National Institute of Neurological Disorders and Stroke, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name><affiliation wicri:level="1"><nlm:aff id="A24">Neuroscience Unit, Department of Neurology, Faculty of Medicine, University of Thessaly, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Neuroscience Unit, Department of Neurology, Faculty of Medicine, University of Thessaly</wicri:regionArea><wicri:noRegion>University of Thessaly</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A36">Department of Neurology, Papageorgiou Hospital, Thessaloniki, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Neurology, Papageorgiou Hospital, Thessaloniki</wicri:regionArea><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Myers, Richard H" sort="Myers, Richard H" uniqKey="Myers R" first="Richard H." last="Myers">Richard H. Myers</name><affiliation wicri:level="2"><nlm:aff id="A10">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Clark, Lorraine N" sort="Clark, Lorraine N" uniqKey="Clark L" first="Lorraine N" last="Clark">Lorraine N. Clark</name><affiliation wicri:level="2"><nlm:aff id="A17">Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Pathology and Cell Biology, Columbia University Medical Center, New York</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A18">The Taub Institute for Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, new York, NY 10032</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>The Taub Institute for Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, new York</wicri:cityArea></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation wicri:level="1"><nlm:aff id="A16">deCODE genetics, Sturlugata 8, IS-101, Reykjavík, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, Sturlugata 8, IS-101, Reykjavík</wicri:regionArea><wicri:noRegion>Reykjavík</wicri:noRegion></affiliation></author><author><name sortKey="Hardy, John A" sort="Hardy, John A" uniqKey="Hardy J" first="John A." last="Hardy">John A. Hardy</name><affiliation><nlm:aff id="A6">Reta Lila Weston Institute, University College London Institute of Neurology, Queen Square, London, United Kingdom, WC1N 3BG</nlm:aff><wicri:noCountry code="subfield">WC1N 3BG</wicri:noCountry></affiliation></author><author><name sortKey="Heutink, Peter" sort="Heutink, Peter" uniqKey="Heutink P" first="Peter" last="Heutink">Peter Heutink</name><affiliation wicri:level="3"><nlm:aff id="A37">Genome Biology for Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Genome Biology for Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Chen, Honglei" sort="Chen, Honglei" uniqKey="Chen H" first="Honglei" last="Chen">Honglei Chen</name><affiliation wicri:level="2"><nlm:aff id="A38">Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, North Carolina</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health</wicri:cityArea></affiliation></author><author><name sortKey="Wood, Nicholas W" sort="Wood, Nicholas W" uniqKey="Wood N" first="Nicholas W." last="Wood">Nicholas W. Wood</name><affiliation wicri:level="4"><nlm:aff id="A13">Department of Molecular Neuroscience, Institute of Neurology, University College London, London, United Kingdom, WC1N 3BG</nlm:aff><orgName type="university">University College de Londres</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Houlden, Henry" sort="Houlden, Henry" uniqKey="Houlden H" first="Henry" last="Houlden">Henry Houlden</name><affiliation wicri:level="4"><nlm:aff id="A13">Department of Molecular Neuroscience, Institute of Neurology, University College London, London, United Kingdom, WC1N 3BG</nlm:aff><orgName type="university">University College de Londres</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Payami, Haydeh" sort="Payami, Haydeh" uniqKey="Payami H" first="Haydeh" last="Payami">Haydeh Payami</name><affiliation wicri:level="2"><nlm:aff id="A39">New York State Department of Health Wadsworth Center, Albany, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>New York State Department of Health Wadsworth Center, Albany, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><affiliation wicri:level="3"><nlm:aff id="A41">Centre National de la Recherche Scientifique, UMR 7225, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre National de la Recherche Scientifique, UMR 7225, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A42">AP-HP, Pitié-Salpêtrière Hospital, Department of Genetics and Cytogenetics, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Pitié-Salpêtrière Hospital, Department of Genetics and Cytogenetics, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Scott, William K" sort="Scott, William K" uniqKey="Scott W" first="William K" last="Scott">William K. Scott</name><affiliation wicri:level="1"><nlm:aff id="A43">Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville TN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville TN</wicri:regionArea><wicri:noRegion>Nashville TN</wicri:noRegion></affiliation></author><author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name><affiliation wicri:level="1"><nlm:aff id="A15">Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen</wicri:regionArea><wicri:noRegion>University of Tübingen</wicri:noRegion><wicri:noRegion>University of Tübingen</wicri:noRegion><wicri:noRegion>University of Tübingen</wicri:noRegion></affiliation></author><author><name sortKey="Bertram, Lars" sort="Bertram, Lars" uniqKey="Bertram L" first="Lars" last="Bertram">Lars Bertram</name><affiliation wicri:level="3"><nlm:aff id="A3">Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Eriksson, Nicholas" sort="Eriksson, Nicholas" uniqKey="Eriksson N" first="Nicholas" last="Eriksson">Nicholas Eriksson</name><affiliation wicri:level="2"><nlm:aff id="A5">23andMe, Inc., Mountain View, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>23andMe, Inc., Mountain View, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name><affiliation wicri:level="2"><nlm:aff id="A44">Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Indiana</region></placeName><wicri:cityArea>Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis</wicri:cityArea></affiliation></author><author><name sortKey="Singleton, Andrew B" sort="Singleton, Andrew B" uniqKey="Singleton A" first="Andrew B." last="Singleton">Andrew B. Singleton</name><affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Neurogenetics, National Institute on Aging, Bethesda</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25064009</idno><idno type="pmc">4146673</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146673</idno><idno type="RBID">PMC:4146673</idno><idno type="doi">10.1038/ng.3043</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000884</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000884</idno><idno type="wicri:Area/Pmc/Curation">000881</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000881</idno><idno type="wicri:Area/Pmc/Checkpoint">000346</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000346</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000516</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000516</idno><idno type="wicri:Area/PubMed/Curation">000501</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000501</idno><idno type="wicri:Area/PubMed/Checkpoint">000501</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000501</idno><idno type="wicri:Area/Ncbi/Merge">001461</idno><idno type="wicri:Area/Ncbi/Curation">001461</idno><idno type="wicri:Area/Ncbi/Checkpoint">001461</idno><idno type="wicri:doubleKey">1061-4036:2014:Nalls M:large:scale:meta</idno><idno type="wicri:Area/Main/Merge">000946</idno><idno type="wicri:Area/Main/Curation">000936</idno><idno type="wicri:Area/Main/Exploration">000936</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson’s disease</title><author><name sortKey="Nalls, Mike A" sort="Nalls, Mike A" uniqKey="Nalls M" first="Mike A" last="Nalls">Mike A. Nalls</name><affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Neurogenetics, National Institute on Aging, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Pankratz, Nathan" sort="Pankratz, Nathan" uniqKey="Pankratz N" first="Nathan" last="Pankratz">Nathan Pankratz</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis</wicri:cityArea></affiliation></author><author><name sortKey="Lill, Christina M" sort="Lill, Christina M" uniqKey="Lill C" first="Christina M." last="Lill">Christina M. Lill</name><affiliation wicri:level="3"><nlm:aff id="A3">Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A4">Department of Neurology, Focus Program Translational Neuroscience, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Focus Program Translational Neuroscience, University Medical Center of the Johannes Gutenberg University Mainz, Mainz</wicri:regionArea><placeName><region type="land" nuts="2">Rhénanie-Palatinat</region><settlement type="city">Mayence</settlement></placeName></affiliation></author><author><name sortKey="Do, Chuong B" sort="Do, Chuong B" uniqKey="Do C" first="Chuong B" last="Do">Chuong B. Do</name><affiliation wicri:level="2"><nlm:aff id="A5">23andMe, Inc., Mountain View, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>23andMe, Inc., Mountain View, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Hernandez, Dena G" sort="Hernandez, Dena G" uniqKey="Hernandez D" first="Dena G." last="Hernandez">Dena G. Hernandez</name><affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Neurogenetics, National Institute on Aging, Bethesda</wicri:cityArea></affiliation><affiliation><nlm:aff id="A6">Reta Lila Weston Institute, University College London Institute of Neurology, Queen Square, London, United Kingdom, WC1N 3BG</nlm:aff><wicri:noCountry code="subfield">WC1N 3BG</wicri:noCountry></affiliation></author><author><name sortKey="Saad, Mohamad" sort="Saad, Mohamad" uniqKey="Saad M" first="Mohamad" last="Saad">Mohamad Saad</name><affiliation wicri:level="4"><nlm:aff id="A7">Department of Biostatistics, University of Washington, Seattle, WA 8195-9460</nlm:aff><orgName type="university">Université de Washington</orgName><country>États-Unis</country><placeName><settlement type="city">Seattle</settlement><region type="state">Washington (État)</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A8">Institut National de la Sante et de la Recherche Medicale, UMR 1043, Centre de Physiopathologie de Toulouse-Purpan, Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Sante et de la Recherche Medicale, UMR 1043, Centre de Physiopathologie de Toulouse-Purpan, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A9">Paul Sabatier University, Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paul Sabatier University, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name><affiliation wicri:level="2"><nlm:aff id="A10">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A11">Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A12">NHLBI’s Framingham Heart Study, Framingham, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>NHLBI’s Framingham Heart Study, Framingham, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Kara, Eleanna" sort="Kara, Eleanna" uniqKey="Kara E" first="Eleanna" last="Kara">Eleanna Kara</name><affiliation wicri:level="4"><nlm:aff id="A13">Department of Molecular Neuroscience, Institute of Neurology, University College London, London, United Kingdom, WC1N 3BG</nlm:aff><orgName type="university">University College de Londres</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Bras, Jose" sort="Bras, Jose" uniqKey="Bras J" first="Jose" last="Bras">Jose Bras</name><affiliation wicri:level="4"><nlm:aff id="A13">Department of Molecular Neuroscience, Institute of Neurology, University College London, London, United Kingdom, WC1N 3BG</nlm:aff><orgName type="university">University College de Londres</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sharma, Manu" sort="Sharma, Manu" uniqKey="Sharma M" first="Manu" last="Sharma">Manu Sharma</name><affiliation wicri:level="1"><nlm:aff id="A14">Institute for Clinical Epidemiology and Applied Biometry, University of Tubingen, Tubingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Clinical Epidemiology and Applied Biometry, University of Tubingen, Tubingen</wicri:regionArea><wicri:noRegion>Tubingen</wicri:noRegion><wicri:noRegion>Tubingen</wicri:noRegion><wicri:noRegion>Tubingen</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A15">Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen</wicri:regionArea><wicri:noRegion>University of Tübingen</wicri:noRegion><wicri:noRegion>University of Tübingen</wicri:noRegion><wicri:noRegion>University of Tübingen</wicri:noRegion></affiliation></author><author><name sortKey="Schulte, Claudia" sort="Schulte, Claudia" uniqKey="Schulte C" first="Claudia" last="Schulte">Claudia Schulte</name><affiliation wicri:level="1"><nlm:aff id="A15">Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen</wicri:regionArea><wicri:noRegion>University of Tübingen</wicri:noRegion><wicri:noRegion>University of Tübingen</wicri:noRegion><wicri:noRegion>University of Tübingen</wicri:noRegion></affiliation></author><author><name sortKey="Keller, Margaux F" sort="Keller, Margaux F" uniqKey="Keller M" first="Margaux F." last="Keller">Margaux F. Keller</name><affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Neurogenetics, National Institute on Aging, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Arepalli, Sampath" sort="Arepalli, Sampath" uniqKey="Arepalli S" first="Sampath" last="Arepalli">Sampath Arepalli</name><affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Neurogenetics, National Institute on Aging, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Letson, Christopher" sort="Letson, Christopher" uniqKey="Letson C" first="Christopher" last="Letson">Christopher Letson</name><affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Neurogenetics, National Institute on Aging, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Edsall, Connor" sort="Edsall, Connor" uniqKey="Edsall C" first="Connor" last="Edsall">Connor Edsall</name><affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Neurogenetics, National Institute on Aging, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Stefansson, Hreinn" sort="Stefansson, Hreinn" uniqKey="Stefansson H" first="Hreinn" last="Stefansson">Hreinn Stefansson</name><affiliation wicri:level="1"><nlm:aff id="A16">deCODE genetics, Sturlugata 8, IS-101, Reykjavík, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, Sturlugata 8, IS-101, Reykjavík</wicri:regionArea><wicri:noRegion>Reykjavík</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Xinmin" sort="Liu, Xinmin" uniqKey="Liu X" first="Xinmin" last="Liu">Xinmin Liu</name><affiliation wicri:level="2"><nlm:aff id="A17">Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Pathology and Cell Biology, Columbia University Medical Center, New York</wicri:cityArea></affiliation></author><author><name sortKey="Pliner, Hannah" sort="Pliner, Hannah" uniqKey="Pliner H" first="Hannah" last="Pliner">Hannah Pliner</name><affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Neurogenetics, National Institute on Aging, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Lee, Joseph H" sort="Lee, Joseph H" uniqKey="Lee J" first="Joseph H." last="Lee">Joseph H. Lee</name><affiliation wicri:level="2"><nlm:aff id="A18">The Taub Institute for Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, new York, NY 10032</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>The Taub Institute for Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, new York</wicri:cityArea></affiliation></author><author><name sortKey="Cheng, Rong" sort="Cheng, Rong" uniqKey="Cheng R" first="Rong" last="Cheng">Rong Cheng</name><affiliation wicri:level="2"><nlm:aff id="A18">The Taub Institute for Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, new York, NY 10032</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>The Taub Institute for Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, new York</wicri:cityArea></affiliation></author><author><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M. Arfan" last="Ikram">M. Arfan Ikram</name><affiliation wicri:level="3"><nlm:aff id="A20">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A21">Department of Radiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Radiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A22">Department of Neurology, Erasmus MC University Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name><affiliation wicri:level="1"><nlm:aff id="A23">Stanford Prevention Research Center, Stanford University, Stanford, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Stanford Prevention Research Center, Stanford University, Stanford</wicri:regionArea><wicri:noRegion>Stanford</wicri:noRegion></affiliation></author><author><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name><affiliation wicri:level="1"><nlm:aff id="A24">Neuroscience Unit, Department of Neurology, Faculty of Medicine, University of Thessaly, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Neuroscience Unit, Department of Neurology, Faculty of Medicine, University of Thessaly</wicri:regionArea><wicri:noRegion>University of Thessaly</wicri:noRegion></affiliation></author><author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name><affiliation wicri:level="2"><nlm:aff id="A25">Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Martinez, Maria" sort="Martinez, Maria" uniqKey="Martinez M" first="Maria" last="Martinez">Maria Martinez</name><affiliation wicri:level="3"><nlm:aff id="A8">Institut National de la Sante et de la Recherche Medicale, UMR 1043, Centre de Physiopathologie de Toulouse-Purpan, Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Sante et de la Recherche Medicale, UMR 1043, Centre de Physiopathologie de Toulouse-Purpan, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A9">Paul Sabatier University, Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Paul Sabatier University, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S." last="Perlmutter">Joel S. Perlmutter</name><affiliation wicri:level="2"><nlm:aff id="A26">Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO 63110</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A27">Department of Radiology, Washington University School of Medicine, St Louis, MO 63110</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Department of Radiology, Washington University School of Medicine, St Louis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A28">Department of Neurology, Washington University School of Medicine, St Louis, MO 63110</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Department of Neurology, Washington University School of Medicine, St Louis</wicri:cityArea></affiliation></author><author><name sortKey="Goate, Alison" sort="Goate, Alison" uniqKey="Goate A" first="Alison" last="Goate">Alison Goate</name><affiliation wicri:level="2"><nlm:aff id="A26">Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO 63110</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A28">Department of Neurology, Washington University School of Medicine, St Louis, MO 63110</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Department of Neurology, Washington University School of Medicine, St Louis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A29">Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Department of Psychiatry, Washington University School of Medicine, St Louis</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A30">Department of Genetics, Washington University School of Medicine, St Louis, MO 63110</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Department of Genetics, Washington University School of Medicine, St Louis</wicri:cityArea></affiliation></author><author><name sortKey="Marder, Karen" sort="Marder, Karen" uniqKey="Marder K" first="Karen" last="Marder">Karen Marder</name><affiliation wicri:level="2"><nlm:aff id="A18">The Taub Institute for Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, new York, NY 10032</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>The Taub Institute for Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, new York</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A31">Gertrude H. Sergievsky Center, Columbia University Medical Center, New York, NY 10032</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Gertrude H. Sergievsky Center, Columbia University Medical Center, New York</wicri:cityArea></affiliation><affiliation><nlm:aff id="A32">Department of Neurology, Columbia University Medical Center. New York</nlm:aff><wicri:noCountry code="subfield">Columbia University Medical Center. New York</wicri:noCountry></affiliation><affiliation><nlm:aff id="A33">Department of Psychiatry, Columbia University Medical Center. New York</nlm:aff><wicri:noCountry code="subfield">Columbia University Medical Center. New York</wicri:noCountry></affiliation></author><author><name sortKey="Fiske, Brian" sort="Fiske, Brian" uniqKey="Fiske B" first="Brian" last="Fiske">Brian Fiske</name><affiliation wicri:level="2"><nlm:aff id="A34">The Michael J. Fox Foundation for Parkinson’s Research, New York, NY</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>The Michael J. Fox Foundation for Parkinson’s Research, New York</wicri:cityArea></affiliation></author><author><name sortKey="Sutherland, Margaret" sort="Sutherland, Margaret" uniqKey="Sutherland M" first="Margaret" last="Sutherland">Margaret Sutherland</name><affiliation wicri:level="2"><nlm:aff id="A35">Neuroscience Center, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Neuroscience Center, National Institute of Neurological Disorders and Stroke, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name><affiliation wicri:level="1"><nlm:aff id="A24">Neuroscience Unit, Department of Neurology, Faculty of Medicine, University of Thessaly, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Neuroscience Unit, Department of Neurology, Faculty of Medicine, University of Thessaly</wicri:regionArea><wicri:noRegion>University of Thessaly</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A36">Department of Neurology, Papageorgiou Hospital, Thessaloniki, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Neurology, Papageorgiou Hospital, Thessaloniki</wicri:regionArea><wicri:noRegion>Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Myers, Richard H" sort="Myers, Richard H" uniqKey="Myers R" first="Richard H." last="Myers">Richard H. Myers</name><affiliation wicri:level="2"><nlm:aff id="A10">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Clark, Lorraine N" sort="Clark, Lorraine N" uniqKey="Clark L" first="Lorraine N" last="Clark">Lorraine N. Clark</name><affiliation wicri:level="2"><nlm:aff id="A17">Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY 10032</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Pathology and Cell Biology, Columbia University Medical Center, New York</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A18">The Taub Institute for Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, new York, NY 10032</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>The Taub Institute for Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, new York</wicri:cityArea></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation wicri:level="1"><nlm:aff id="A16">deCODE genetics, Sturlugata 8, IS-101, Reykjavík, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics, Sturlugata 8, IS-101, Reykjavík</wicri:regionArea><wicri:noRegion>Reykjavík</wicri:noRegion></affiliation></author><author><name sortKey="Hardy, John A" sort="Hardy, John A" uniqKey="Hardy J" first="John A." last="Hardy">John A. Hardy</name><affiliation><nlm:aff id="A6">Reta Lila Weston Institute, University College London Institute of Neurology, Queen Square, London, United Kingdom, WC1N 3BG</nlm:aff><wicri:noCountry code="subfield">WC1N 3BG</wicri:noCountry></affiliation></author><author><name sortKey="Heutink, Peter" sort="Heutink, Peter" uniqKey="Heutink P" first="Peter" last="Heutink">Peter Heutink</name><affiliation wicri:level="3"><nlm:aff id="A37">Genome Biology for Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Genome Biology for Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE), Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Chen, Honglei" sort="Chen, Honglei" uniqKey="Chen H" first="Honglei" last="Chen">Honglei Chen</name><affiliation wicri:level="2"><nlm:aff id="A38">Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, North Carolina</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health</wicri:cityArea></affiliation></author><author><name sortKey="Wood, Nicholas W" sort="Wood, Nicholas W" uniqKey="Wood N" first="Nicholas W." last="Wood">Nicholas W. Wood</name><affiliation wicri:level="4"><nlm:aff id="A13">Department of Molecular Neuroscience, Institute of Neurology, University College London, London, United Kingdom, WC1N 3BG</nlm:aff><orgName type="university">University College de Londres</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Houlden, Henry" sort="Houlden, Henry" uniqKey="Houlden H" first="Henry" last="Houlden">Henry Houlden</name><affiliation wicri:level="4"><nlm:aff id="A13">Department of Molecular Neuroscience, Institute of Neurology, University College London, London, United Kingdom, WC1N 3BG</nlm:aff><orgName type="university">University College de Londres</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Payami, Haydeh" sort="Payami, Haydeh" uniqKey="Payami H" first="Haydeh" last="Payami">Haydeh Payami</name><affiliation wicri:level="2"><nlm:aff id="A39">New York State Department of Health Wadsworth Center, Albany, NY, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>New York State Department of Health Wadsworth Center, Albany, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><affiliation wicri:level="3"><nlm:aff id="A41">Centre National de la Recherche Scientifique, UMR 7225, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre National de la Recherche Scientifique, UMR 7225, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A42">AP-HP, Pitié-Salpêtrière Hospital, Department of Genetics and Cytogenetics, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Pitié-Salpêtrière Hospital, Department of Genetics and Cytogenetics, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Scott, William K" sort="Scott, William K" uniqKey="Scott W" first="William K" last="Scott">William K. Scott</name><affiliation wicri:level="1"><nlm:aff id="A43">Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville TN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville TN</wicri:regionArea><wicri:noRegion>Nashville TN</wicri:noRegion></affiliation></author><author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name><affiliation wicri:level="1"><nlm:aff id="A15">Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen</wicri:regionArea><wicri:noRegion>University of Tübingen</wicri:noRegion><wicri:noRegion>University of Tübingen</wicri:noRegion><wicri:noRegion>University of Tübingen</wicri:noRegion></affiliation></author><author><name sortKey="Bertram, Lars" sort="Bertram, Lars" uniqKey="Bertram L" first="Lars" last="Bertram">Lars Bertram</name><affiliation wicri:level="3"><nlm:aff id="A3">Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neuropsychiatric Genetics Group, Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Eriksson, Nicholas" sort="Eriksson, Nicholas" uniqKey="Eriksson N" first="Nicholas" last="Eriksson">Nicholas Eriksson</name><affiliation wicri:level="2"><nlm:aff id="A5">23andMe, Inc., Mountain View, California, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>23andMe, Inc., Mountain View, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name><affiliation wicri:level="2"><nlm:aff id="A44">Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Indiana</region></placeName><wicri:cityArea>Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis</wicri:cityArea></affiliation></author><author><name sortKey="Singleton, Andrew B" sort="Singleton, Andrew B" uniqKey="Singleton A" first="Andrew B." last="Singleton">Andrew B. Singleton</name><affiliation wicri:level="2"><nlm:aff id="A1">Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Neurogenetics, National Institute on Aging, Bethesda</wicri:cityArea></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="ISSN">1061-4036</idno><idno type="eISSN">1546-1718</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Case-Control Studies</term><term>Genetic Loci</term><term>Genetic Predisposition to Disease</term><term>Genome-Wide Association Study (methods)</term><term>Genotype</term><term>Humans</term><term>Parkinson Disease (genetics)</term><term>Polymorphism, Single Nucleotide</term><term>Risk Factors</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Genome-Wide Association Study</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Case-Control Studies</term><term>Genetic Loci</term><term>Genetic Predisposition to Disease</term><term>Genotype</term><term>Humans</term><term>Polymorphism, Single Nucleotide</term><term>Risk Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">We conducted a meta analysis of Parkinson’s disease genome-wide association studies using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty-six loci were identified as genome-wide significant; these and six additional previously reported loci were then tested in an independent set of 5,353 cases and 5,551 controls. Of the 32 tested SNPs, 24 replicated, including 6 novel loci. Conditional analyses within loci show four loci including <italic>GBA</italic>, <italic>GAK/DGKQ</italic>, <italic>SNCA</italic>, and <italic>HLA</italic> contain a secondary independent risk variant. In total we identified and replicated 28 independent risk variants for Parkinson disease across 24 loci. While the effect of each individual locus is small, a risk profile analysis revealed a substantial cummulative risk in a comparison highest versus lowest quintiles of genetic risk (OR=3.31, 95% CI: 2.55, 4.30; p-value = 2×10<sup>−16</sup>). We also show 6 risk loci associated with proximal gene expression or DNA methylation.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Lill, Cm" uniqKey="Lill C">CM Lill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Do, Cb" uniqKey="Do C">CB Do</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Edwards, Tl" uniqKey="Edwards T">TL Edwards</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pankratz, N" uniqKey="Pankratz N">N Pankratz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pankratz, N" uniqKey="Pankratz N">N Pankratz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sim N Sanchez, J" uniqKey="Sim N Sanchez J">J Simón-Sánchez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hamza, Th" uniqKey="Hamza T">TH Hamza</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, X" uniqKey="Liu X">X Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hernandez, Dg" uniqKey="Hernandez D">DG Hernandez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pihlstr M, L" uniqKey="Pihlstr M L">L Pihlstrøm</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sharma, M" uniqKey="Sharma M">M Sharma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saad, M" uniqKey="Saad M">M Saad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Satake, W" uniqKey="Satake W">W Satake</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Elbaz, A" uniqKey="Elbaz A">A Elbaz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Psaty, Bm" uniqKey="Psaty B">BM Psaty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Macleod, Da" uniqKey="Macleod D">DA Macleod</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Keller, Mf" uniqKey="Keller M">MF Keller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wei, Z" uniqKey="Wei Z">Z Wei</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Willems, Sm" uniqKey="Willems S">SM Willems</name></author><author><name sortKey="Mihaescu, R" uniqKey="Mihaescu R">R Mihaescu</name></author><author><name sortKey="Sijbrands, Ejg" uniqKey="Sijbrands E">EJG Sijbrands</name></author><author><name sortKey="Van Duijn, Cm" uniqKey="Van Duijn C">CM van Duijn</name></author><author><name sortKey="Janssens, Acjw" uniqKey="Janssens A">ACJW Janssens</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="De Bakker, Piw" uniqKey="De Bakker P">PIW De Bakker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Der Walt, Jm" uniqKey="Van Der Walt J">JM Van der Walt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gibbs, Jr" uniqKey="Gibbs J">JR Gibbs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hofman, A" uniqKey="Hofman A">A Hofman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ton, Tg" uniqKey="Ton T">TG Ton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ikram, Ma" uniqKey="Ikram M">MA Ikram</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eriksson, N" uniqKey="Eriksson N">N Eriksson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Howie, B" uniqKey="Howie B">B Howie</name></author><author><name sortKey="Fuchsberger, C" uniqKey="Fuchsberger C">C Fuchsberger</name></author><author><name sortKey="Stephens, M" uniqKey="Stephens M">M Stephens</name></author><author><name sortKey="Marchini, J" uniqKey="Marchini J">J Marchini</name></author><author><name sortKey="Abecasis, Gr" uniqKey="Abecasis G">GR Abecasis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Willer, Cj" uniqKey="Willer C">CJ Willer</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Abecasis, Gr" uniqKey="Abecasis G">GR Abecasis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Han, B" uniqKey="Han B">B Han</name></author><author><name sortKey="Eskin, E" uniqKey="Eskin E">E Eskin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Grove, Ml" uniqKey="Grove M">ML Grove</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ripatti, S" uniqKey="Ripatti S">S Ripatti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hernandez, Dg" uniqKey="Hernandez D">DG Hernandez</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>France</li><li>Grèce</li><li>Islande</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Bade-Wurtemberg</li><li>Berlin</li><li>Californie</li><li>Caroline du Nord</li><li>District de Tübingen</li><li>Grand Londres</li><li>Hollande-Méridionale</li><li>Indiana</li><li>Maryland</li><li>Massachusetts</li><li>Midi-Pyrénées</li><li>Minnesota</li><li>Missouri (État)</li><li>Occitanie (région administrative)</li><li>Rhénanie-Palatinat</li><li>Washington (État)</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Berlin</li><li>Londres</li><li>Mayence</li><li>Paris</li><li>Rotterdam</li><li>Seattle</li><li>Toulouse</li><li>Tübingen</li></settlement><orgName><li>University College de Londres</li><li>Université de Washington</li></orgName></list><tree><noCountry><name sortKey="Hardy, John A" sort="Hardy, John A" uniqKey="Hardy J" first="John A." last="Hardy">John A. Hardy</name></noCountry><country name="États-Unis"><region name="Maryland"><name sortKey="Nalls, Mike A" sort="Nalls, Mike A" uniqKey="Nalls M" first="Mike A" last="Nalls">Mike A. Nalls</name></region><name sortKey="Arepalli, Sampath" sort="Arepalli, Sampath" uniqKey="Arepalli S" first="Sampath" last="Arepalli">Sampath Arepalli</name><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name><name sortKey="Chen, Honglei" sort="Chen, Honglei" uniqKey="Chen H" first="Honglei" last="Chen">Honglei Chen</name><name sortKey="Cheng, Rong" sort="Cheng, Rong" uniqKey="Cheng R" first="Rong" last="Cheng">Rong Cheng</name><name sortKey="Clark, Lorraine N" sort="Clark, Lorraine N" uniqKey="Clark L" first="Lorraine N" last="Clark">Lorraine N. Clark</name><name sortKey="Clark, Lorraine N" sort="Clark, Lorraine N" uniqKey="Clark L" first="Lorraine N" last="Clark">Lorraine N. Clark</name><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name><name sortKey="Do, Chuong B" sort="Do, Chuong B" uniqKey="Do C" first="Chuong B" last="Do">Chuong B. Do</name><name sortKey="Edsall, Connor" sort="Edsall, Connor" uniqKey="Edsall C" first="Connor" last="Edsall">Connor Edsall</name><name sortKey="Eriksson, Nicholas" sort="Eriksson, Nicholas" uniqKey="Eriksson N" first="Nicholas" last="Eriksson">Nicholas Eriksson</name><name sortKey="Fiske, Brian" sort="Fiske, Brian" uniqKey="Fiske B" first="Brian" last="Fiske">Brian Fiske</name><name sortKey="Foroud, Tatiana" sort="Foroud, Tatiana" uniqKey="Foroud T" first="Tatiana" last="Foroud">Tatiana Foroud</name><name sortKey="Goate, Alison" sort="Goate, Alison" uniqKey="Goate A" first="Alison" last="Goate">Alison Goate</name><name sortKey="Goate, Alison" sort="Goate, Alison" uniqKey="Goate A" first="Alison" last="Goate">Alison Goate</name><name sortKey="Goate, Alison" sort="Goate, Alison" uniqKey="Goate A" first="Alison" last="Goate">Alison Goate</name><name sortKey="Goate, Alison" sort="Goate, Alison" uniqKey="Goate A" first="Alison" last="Goate">Alison Goate</name><name sortKey="Hernandez, Dena G" sort="Hernandez, Dena G" uniqKey="Hernandez D" first="Dena G." last="Hernandez">Dena G. Hernandez</name><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John P. A." last="Ioannidis">John P. A. Ioannidis</name><name sortKey="Keller, Margaux F" sort="Keller, Margaux F" uniqKey="Keller M" first="Margaux F." last="Keller">Margaux F. Keller</name><name sortKey="Lee, Joseph H" sort="Lee, Joseph H" uniqKey="Lee J" first="Joseph H." last="Lee">Joseph H. Lee</name><name sortKey="Letson, Christopher" sort="Letson, Christopher" uniqKey="Letson C" first="Christopher" last="Letson">Christopher Letson</name><name sortKey="Liu, Xinmin" sort="Liu, Xinmin" uniqKey="Liu X" first="Xinmin" last="Liu">Xinmin Liu</name><name sortKey="Marder, Karen" sort="Marder, Karen" uniqKey="Marder K" first="Karen" last="Marder">Karen Marder</name><name sortKey="Marder, Karen" sort="Marder, Karen" uniqKey="Marder K" first="Karen" last="Marder">Karen Marder</name><name sortKey="Myers, Richard H" sort="Myers, Richard H" uniqKey="Myers R" first="Richard H." last="Myers">Richard H. Myers</name><name sortKey="Pankratz, Nathan" sort="Pankratz, Nathan" uniqKey="Pankratz N" first="Nathan" last="Pankratz">Nathan Pankratz</name><name sortKey="Payami, Haydeh" sort="Payami, Haydeh" uniqKey="Payami H" first="Haydeh" last="Payami">Haydeh Payami</name><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S." last="Perlmutter">Joel S. Perlmutter</name><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S." last="Perlmutter">Joel S. Perlmutter</name><name sortKey="Perlmutter, Joel S" sort="Perlmutter, Joel S" uniqKey="Perlmutter J" first="Joel S." last="Perlmutter">Joel S. Perlmutter</name><name sortKey="Pliner, Hannah" sort="Pliner, Hannah" uniqKey="Pliner H" first="Hannah" last="Pliner">Hannah Pliner</name><name sortKey="Saad, Mohamad" sort="Saad, Mohamad" uniqKey="Saad M" first="Mohamad" last="Saad">Mohamad Saad</name><name sortKey="Scott, William K" sort="Scott, William K" uniqKey="Scott W" first="William K" last="Scott">William K. Scott</name><name sortKey="Singleton, Andrew B" sort="Singleton, Andrew B" uniqKey="Singleton A" first="Andrew B." last="Singleton">Andrew B. Singleton</name><name sortKey="Sutherland, Margaret" sort="Sutherland, Margaret" uniqKey="Sutherland M" first="Margaret" last="Sutherland">Margaret Sutherland</name></country><country name="Allemagne"><region name="Berlin"><name sortKey="Lill, Christina M" sort="Lill, Christina M" uniqKey="Lill C" first="Christina M." last="Lill">Christina M. Lill</name></region><name sortKey="Bertram, Lars" sort="Bertram, Lars" uniqKey="Bertram L" first="Lars" last="Bertram">Lars Bertram</name><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name><name sortKey="Heutink, Peter" sort="Heutink, Peter" uniqKey="Heutink P" first="Peter" last="Heutink">Peter Heutink</name><name sortKey="Lill, Christina M" sort="Lill, Christina M" uniqKey="Lill C" first="Christina M." last="Lill">Christina M. Lill</name><name sortKey="Schulte, Claudia" sort="Schulte, Claudia" uniqKey="Schulte C" first="Claudia" last="Schulte">Claudia Schulte</name><name sortKey="Sharma, Manu" sort="Sharma, Manu" uniqKey="Sharma M" first="Manu" last="Sharma">Manu Sharma</name><name sortKey="Sharma, Manu" sort="Sharma, Manu" uniqKey="Sharma M" first="Manu" last="Sharma">Manu Sharma</name></country><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Saad, Mohamad" sort="Saad, Mohamad" uniqKey="Saad M" first="Mohamad" last="Saad">Mohamad Saad</name></region><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><name sortKey="Martinez, Maria" sort="Martinez, Maria" uniqKey="Martinez M" first="Maria" last="Martinez">Maria Martinez</name><name sortKey="Martinez, Maria" sort="Martinez, Maria" uniqKey="Martinez M" first="Maria" last="Martinez">Maria Martinez</name><name sortKey="Saad, Mohamad" sort="Saad, Mohamad" uniqKey="Saad M" first="Mohamad" last="Saad">Mohamad Saad</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Kara, Eleanna" sort="Kara, Eleanna" uniqKey="Kara E" first="Eleanna" last="Kara">Eleanna Kara</name></region><name sortKey="Bras, Jose" sort="Bras, Jose" uniqKey="Bras J" first="Jose" last="Bras">Jose Bras</name><name sortKey="Houlden, Henry" sort="Houlden, Henry" uniqKey="Houlden H" first="Henry" last="Houlden">Henry Houlden</name><name sortKey="Wood, Nicholas W" sort="Wood, Nicholas W" uniqKey="Wood N" first="Nicholas W." last="Wood">Nicholas W. Wood</name></country><country name="Islande"><noRegion><name sortKey="Stefansson, Hreinn" sort="Stefansson, Hreinn" uniqKey="Stefansson H" first="Hreinn" last="Stefansson">Hreinn Stefansson</name></noRegion><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M. Arfan" last="Ikram">M. Arfan Ikram</name></region><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M. Arfan" last="Ikram">M. Arfan Ikram</name><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M. Arfan" last="Ikram">M. Arfan Ikram</name></country><country name="Grèce"><noRegion><name sortKey="Hadjigeorgiou, Georgios M" sort="Hadjigeorgiou, Georgios M" uniqKey="Hadjigeorgiou G" first="Georgios M." last="Hadjigeorgiou">Georgios M. Hadjigeorgiou</name></noRegion><name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name><name sortKey="Xiromerisiou, Georgia" sort="Xiromerisiou, Georgia" uniqKey="Xiromerisiou G" first="Georgia" last="Xiromerisiou">Georgia Xiromerisiou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000936 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000936 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4146673
|texte= Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson’s disease
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25064009" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |